GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs1109501 | 1 | rs1109501 | chr4:71329490 | AMTN | chr4:71384298-71398459:+ | 0.26 | 4.22 | 3.01E-5 | Alcoholism (heaviness of drinking) |
| BLCA | cis | rs13256369 | 1 | rs1109619 | chr8:8571616 | CLDN23 | chr8:8559666-8561616:+ | -0.23 | -3.87 | 0.000127 | Obesity-related traits |
| BLCA | cis | rs17030613 | 1 | rs1110042 | chr1:113236534 | ST7L | chr1:113066142-113162405:- | 0.44 | 6.49 | 2.68E-10 | Diastolic blood pressure;Blood pressure |
| BLCA | cis | rs1110183 | 1 | rs1110183 | chr9:38456365 | MCART1 | chr9:37877572-37904350:- | 0.23 | 4.13 | 4.48E-5 | Hypertension |
| BLCA | cis | rs11123170 | 1 | rs11123170 | chr2:113978940 | LOC654433 | chr2:113993107-114024579:+ | -0.36 | -5.64 | 3.35E-8 | Renal function-related traits (BUN) |
| BLCA | cis | rs11123170 | 1 | rs11123170 | chr2:113978940 | PAX8 | chr2:113973575-114036498:- | -0.3 | -4.85 | 1.83E-6 | Renal function-related traits (BUN) |
| BLCA | cis | rs4372836 | 1 | rs11127188 | chr2:28972852 | TRMT61B | chr2:29072690-29093175:- | -0.31 | -5.41 | 1.12E-7 | Body mass index |
| BLCA | cis | rs2241437 | 1 | rs111295372 | chr2:86283357 | LOC90784 | chr2:86247339-86250991:- | -0.41 | -4.21 | 3.18E-5 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| BLCA | cis | rs9876781 | 1 | rs11130170 | chr3:48449897 | TREX1 | chr3:48501186-48509043:+ | -0.19 | -3.86 | 0.000134 | Longevity |
| BLCA | cis | rs111315781 | 1 | rs111315781 | chr2:201738724 | PPIL3 | chr2:201735680-201753999:- | -0.71 | -8.23 | 3.02E-15 | Triptolide cytotoxicity |
| BLCA | cis | rs2130392 | 1 | rs11132254 | chr4:185611592 | MLF1IP | chr4:185615220-185655286:- | -0.47 | -10.86 | 3.96E-24 | Kawasaki disease |
| BLCA | cis | rs9309473 | 1 | rs1114380 | chr2:73804708 | ALMS1P | chr2:73872046-73912692:+ | 0.36 | 5.33 | 1.7E-7 | Metabolite levels |
| BLCA | cis | rs2143950 | 1 | rs11156875 | chr14:35619816 | PPP2R3C | chr14:35554679-35591679:- | 0.24 | 4.03 | 6.59E-5 | Atopic dermatitis |
| BLCA | cis | rs11158609 | 1 | rs11158609 | chr14:24688814 | TGM1 | chr14:24718322-24732416:- | 0.28 | 3.9 | 0.000111 | Systolic blood pressure (cigarette smoking interaction) |
| BLCA | cis | rs2239557 | 1 | rs11159067 | chr14:74637444 | LIN52 | chr14:74551656-74667117:+ | 0.33 | 7.81 | 5.66E-14 | Common traits (Other) |